Anthony Reynolds organised his first exhibitions in the North West of England in 1969. In 1970 he staged what was then the largest exhibition of contemporary British photography, including over 400 works. From 1976 to 1982 he was Regional Art Officer for the Arts Council of Great Britain, supervising the distribution of grants to artists and artists organisations nationwide. In 1982 his Collazione Inglese was the first exhibition to take place in Venice as an autonomous intervention at the Biennale. This was repeated in 1984. After three years operating as an artist's agency Anthony Reynolds Gallery opened in large space on the edge of the City of London in 1985.

Over the next 35 years, in three successive premises, the gallery staged 230 exhibitions including the work of over 300 artists from 27 countries. We currently support 18 artists. Gallery artists have won over 100 major international awards and are represented in major museum collections worldwide.

In 2015 we took the decision to adopt a new model and to maintain all the activities of a primary gallery but without a fixed exhibition space. This allows us to collaborate with our professional colleagues in exhibiting artists in the best or most productive context for their work whether in terms of space, of programme, of geography or of clientele. This we see as a mutually beneficial economic model. It also allows us the flexibility to adapt to external financial or social upheaval.

In 2020 the gallery launched a satellite domain www.pataphysic.com to act as a host for idiosyncratic projects and ideas, another alternative space By extending opportunities for artist and galleries alike, by sharing experience and resources and by adapting to the needs and desires of the viewing and collecting public, we hope to offer opportunities that celebrate the importance of difference within a homogeneous practice.